Description
Avastin (bevacizumab) Concentrate for Infusion 100 mg/4 ml.
Avastin, also known by its generic name bevacizumab, is a medication that is administered as a concentrate for infusions. Each vial contains 100 mg. of the active ingredient in a 4 ml. solution. Avastin is widely used in the treatment of various cancers and other conditions where abnormal blood vessel growth plays a role.
Indications
Avastin is commonly prescribed for the treatment of:
- Colorectal cancer
- Lung cancer
- Breast cancer
- Glioblastoma (a type of brain tumor)
- Ovarian cancer
- Cervical cancer
Mechanism of Action
Bevacizumab is a monoclonal antibody that works by targeting and inhibiting vascular endothelial growth factor (VEGF). VEGF is a protein that stimulates the growth of new blood vessels. By blocking VEGF, Avastin helps to prevent the formation of new blood vessels that supply nutrients to tumors, ultimately slowing down tumor growth and spread.
Administration
Avastin is administered intravenously as an infusion. The concentration of 100 mg/4 ml. means that the contents of the vial need to be mixed with a specific volume of diluent before being administered to the patient. The exact dosage and dilution will be determined by the healthcare provider based on the patient’s weight, medical condition, and the specific indication for which Avastin is being prescribed.
Side Effects
Like all medications, Avastin can cause side effects. Some common side effects of Avastin may include:
- Fatigue
- High blood pressure
- Proteinuria (excess protein in the urine)
- Nosebleeds
- Headache
- Decreased appetite
It is important to report any side effects to your healthcare provider promptly. In some cases, Avastin may cause more serious side effects, such as gastrointestinal perforation, wound healing complications, and severe bleeding. Your healthcare provider will monitor you closely for any signs of these complications.
Precautions
Before starting treatment with Avastin, inform your healthcare provider about any pre-existing medical conditions and medications you are taking. Avastin may interact with certain medications and medical conditions, so it is important to provide a comprehensive medical history to your healthcare provider.
It is also important to use effective contraception during treatment with Avastin, as it may harm an unborn baby. If you are pregnant or planning to become pregnant, discuss the risks and benefits of Avastin with your healthcare provider.
Storage
Avastin vials should be stored in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). Do not freeze the vials, and protect them from light. Once the vial is opened and diluted, it should be used immediately or stored according to the manufacturer’s instructions.
Conclusion
Avastin (bevacizumab) is a valuable medication in the treatment of various cancers and conditions involving abnormal blood vessel growth. By targeting VEGF, Avastin helps to inhibit tumor growth and improve patient outcomes. It is important to follow your healthcare provider’s instructions for the administration and monitoring of Avastin to ensure the best possible treatment results.
