Description
Co-Amlessa 4 mg/1.25 mg/10 mg. #30 Tablets
What is Co-Amlessa and How Does it Work?
Co-Amlessa is a combination medication that contains three active ingredients: perindopril tert-butylamine, indapamide, and amlodipine. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor, indapamide is a diuretic, and amlodipine is a calcium channel blocker.
Perindopril works by relaxing blood vessels, making it easier for the heart to pump blood around the body. Indapamide helps the body to remove excess water and salt through urine, reducing blood volume and lowering blood pressure. Amlodipine relaxes and widens blood vessels, making it easier for the heart to pump blood and lowering blood pressure.
Indications and Uses
Co-Amlessa tablets are primarily used to treat high blood pressure (hypertension) in patients who require multiple medications to control their blood pressure. It is also prescribed to reduce the risk of cardiovascular events such as heart attacks and strokes in patients with hypertension.
Dosage and Administration
The usual recommended dose of Co-Amlessa tablets is one tablet taken once daily, preferably in the morning. The tablets should be swallowed whole with a glass of water and can be taken with or without food. It is important to take the medication exactly as prescribed by your healthcare provider.
If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule should be resumed. Do not double the dose to make up for a missed one.
Contraindications
Co-Amlessa tablets are contraindicated in patients who are allergic to any of the active ingredients (perindopril, indapamide, amlodipine) or any other components of the medication. It should not be used in patients with a history of angioedema related to previous ACE inhibitor therapy, severe liver disease, or severe kidney impairment.
Additionally, Co-Amlessa should not be used during pregnancy or breastfeeding unless the potential benefits outweigh the risks. It is important to discuss the risks and benefits with your healthcare provider before starting this medication.
Warnings and Precautions
Before starting Co-Amlessa tablets, inform your healthcare provider about any existing medical conditions, including kidney disease, liver disease, heart disease, diabetes, or electrolyte imbalances. These conditions may require special monitoring or dose adjustments while taking this medication.
It is essential to monitor blood pressure regularly while on Co-Amlessa therapy and report any significant changes to your healthcare provider. This medication may cause dizziness or lightheadedness, especially during the initial days of treatment, so caution is advised when driving or operating machinery.
Adverse Reactions
Common side effects of Co-Amlessa tablets may include dizziness, headache, fatigue, cough, and swelling of the ankles. These side effects are usually mild and transient, but if they persist or worsen, contact your healthcare provider.
Serious side effects that may require immediate medical attention include severe allergic reactions, chest pain, irregular heartbeat, shortness of breath, and signs of kidney problems such as changes in urine output or color.
Drug Interactions
Co-Amlessa tablets may interact with other medications, including potassium-sparing diuretics, potassium supplements, nonsteroidal anti-inflammatory drugs (NSAIDs), and certain antidiabetic drugs. Inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.
Storage and Handling
Co-Amlessa tablets should be stored at room temperature away from moisture and heat. Keep the medication out of reach of children and pets. Do not use the tablets after the expiration date printed on the packaging.
Conclusion
Co-Amlessa tablets are a combination medication used to treat high blood pressure and reduce the risk of cardiovascular events in patients with hypertension. It combines the actions of an ACE inhibitor, a diuretic, and a calcium channel blocker to effectively lower blood pressure and improve cardiovascular outcomes.
It is essential to follow the prescribed dosing regimen, monitor for side effects, and report any concerns to your healthcare provider while on Co-Amlessa therapy. With proper use and monitoring, Co-Amlessa can help manage hypertension and improve overall cardiovascular health.
