Description
Co-Diroton Tablets 20 mg/12.5 mg.
Co-Diroton tablets are a medication that combines two active ingredients, 20 mg. of perindopril and 12.5 mg. of indapamide. This combination is commonly used to treat high blood pressure, also known as hypertension, in adults. The medication is available in a pack of 30 tablets.
Perindopril
Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking the action of ACE, an enzyme that causes blood vessels to narrow. By inhibiting ACE, perindopril helps relax and widen the blood vessels, which in turn lowers blood pressure. This can help reduce the risk of heart attacks, strokes, and other cardiovascular events.
Indapamide
Indapamide is a thiazide-like diuretic, which means it helps the body get rid of excess water and salt through urine. By promoting the excretion of water and salt, indapamide helps reduce the volume of blood in the vessels, which can lower blood pressure. It also has vasodilatory effects, which further aid in lowering blood pressure.
Indications
Co-Diroton tablets are indicated for the treatment of high blood pressure in adults. They are often prescribed when blood pressure is not adequately controlled by monotherapy with either perindopril or indapamide alone. The combination of these two medications in Co-Diroton tablets provides a synergistic effect in lowering blood pressure.
Contraindications
Co-Diroton tablets are contraindicated in patients with a history of hypersensitivity to perindopril, indapamide, other ACE inhibitors, sulfonamides, or any other component of the medication. They should not be used in patients with a history of angioedema related to previous ACE inhibitor therapy. Co-Diroton tablets should also be avoided in patients with severe renal impairment (creatinine clearance <30 mL/min) or severe hepatic impairment.
Warnings and Precautions
Before taking Co-Diroton tablets, patients should inform their healthcare provider about any medical conditions they have, especially if they have kidney disease, liver disease, heart disease, diabetes, or electrolyte imbalances. It is important to monitor blood pressure regularly while taking Co-Diroton tablets and adjust the dosage as needed. Patients should also be cautious when driving or operating machinery, as Co-Diroton tablets may cause dizziness or drowsiness.
Adverse Reactions
Common side effects of Co-Diroton tablets may include dizziness, headache, fatigue, cough, nausea, and hypotension (low blood pressure). Less common but more serious side effects may include angioedema, renal failure, hyperkalemia (high potassium levels), and electrolyte imbalances. If any adverse reactions occur while taking Co-Diroton tablets, patients should seek medical attention immediately.
Dosage and Administration
The usual dose of Co-Diroton tablets is one tablet taken orally once daily, preferably in the morning. The tablets should be swallowed whole with a glass of water and can be taken with or without food. The dosage may be adjusted by a healthcare provider based on the individual patient’s response to treatment and blood pressure goals.
Storage
Co-Diroton tablets should be stored at room temperature away from moisture and heat. Keep the medication out of reach of children and pets. Do not use Co-Diroton tablets after the expiration date printed on the packaging.
Conclusion
Co-Diroton tablets are a combination medication used to treat high blood pressure in adults. By combining perindopril, an ACE inhibitor, with indapamide, a diuretic, Co-Diroton tablets provide an effective way to lower blood pressure and reduce the risk of cardiovascular events. Patients should follow their healthcare provider’s instructions on dosage and monitoring while taking Co-Diroton tablets to ensure safe and effective treatment.
