Description
Combipril (amlodipine, lisinopril) Tablets 5 mg/10 mg.
Combipril is a combination medication containing two active ingredients, amlodipine and lisinopril, in each tablet. Amlodipine belongs to a class of drugs known as calcium channel blockers, while lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. This combination of medications is commonly used to treat high blood pressure (hypertension) and certain heart conditions.
Indications
Combipril tablets are indicated for the treatment of hypertension in patients who require dual therapy for optimal blood pressure control. It is also used in patients with heart failure and other heart-related conditions to improve symptoms and reduce the risk of cardiovascular events.
Mechanism of Action
Amlodipine works by relaxing the blood vessels, allowing for easier blood flow and reducing the workload on the heart. Lisinopril helps to lower blood pressure by inhibiting the action of angiotensin-converting enzyme, which is responsible for the production of angiotensin II, a potent vasoconstrictor.
Dosage and Administration
Combipril tablets are available in the strength of 5 mg. amlodipine and 10 mg. lisinopril. The usual recommended dose is one tablet once daily, taken orally with or without food. It is important to follow the dosage instructions provided by your healthcare provider and not to exceed the prescribed dose.
Precautions and Warnings
Before taking Combipril, inform your healthcare provider about any medical conditions you have, especially kidney disease, liver disease, heart disease, or diabetes. It is important to monitor your blood pressure regularly while taking this medication and report any significant changes to your doctor.
Side Effects
Common side effects of Combipril may include dizziness, lightheadedness, headache, cough, and fatigue. In rare cases, more serious side effects such as allergic reactions, swelling of the face or throat, or severe dizziness may occur. If you experience any severe side effects, seek immediate medical attention.
Drug Interactions
Combipril may interact with other medications, including potassium-sparing diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), and certain antibiotics. It is important to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.
Storage
Store Combipril tablets in a cool, dry place away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Do not use Combipril past the expiration date printed on the packaging.
Conclusion
Combipril is a combination medication used for the treatment of hypertension and certain heart conditions. It combines the benefits of a calcium channel blocker and an ACE inhibitor to provide effective blood pressure control and cardiovascular protection. It is important to follow the prescribed dosage and recommendations of your healthcare provider while taking Combipril to ensure optimal results and minimize the risk of side effects.
