Description
Injesta 1% Ampoules 1 ml #5
Injesta 1% ampoules are an injectable form of progesterone, used to manage a range of gynecological and reproductive conditions. This medication aids in maintaining pregnancy and balancing menstrual cycles when administered under professional healthcare guidance. Each package contains 5 ampoules, with each ampoule holding 1 ml of the solution.
Composition
Each 1 ml of Injesta 1% solution contains the following:
- Active ingredient: Progesterone 10 mg
- Other component: Ethyloleate
Dosage Form
Solution for injection at a concentration of 1%.
Physical and Chemical Properties
Injesta 1% is a light yellow or light green oily liquid with a characteristic smell.
Pharmacotherapeutic Group
Classified as a progestogen. ATC code: G03DA04.
Pharmacological Properties
Pharmacodynamics
Progesterone, the main ingredient in Injesta, helps transition the uterine lining to the secretory phase, facilitating embryo implantation and supporting early pregnancy. It also lowers uterine muscle activity, assists in breast tissue development, and ensures hormonal balance necessary for menstrual regulation and pregnancy maintenance.
Pharmacokinetics
When administered intramuscularly or subcutaneously, Injesta is quickly absorbed and metabolized primarily in the liver. The major metabolite, pregnanediol, is excreted via the urine. A small portion of the drug is stored in subcutaneous fat tissue.
Indications
Injesta 1% ampoules are prescribed for the treatment of:
- Amenorrhea (absence of menstruation)
- Non-ovulatory uterine bleeding
- Endocrine-related infertility
- Preventing miscarriage
- Oligomenorrhea and dysmenorrhea (irregular and painful periods)
Contraindications
Injesta should not be used in patients with the following conditions:
- Liver diseases or liver dysfunction
- Breast or reproductive organ tumors
- Blood clotting disorders or thromboembolism
- Severe depression or porphyria
- Pregnancy after 36 weeks
- Unexplained vaginal bleeding
Drug Interactions
Injesta can interact with other medications, such as oxytocin, diuretics, and immunosuppressants. It may enhance the effects of diuretics and blood-thinning medications, while reducing the effectiveness of anabolic steroids and oxytocin.
Precautions
Caution is advised when using Injesta in patients with cardiovascular diseases, hypertension, diabetes, or depression. Continuous monitoring is required for those with a history of blood clots. Since progesterone is metabolized in the liver, it is not recommended for patients with liver disorders.
Use During Pregnancy and Breastfeeding
Injesta may be used during early pregnancy to prevent miscarriage but is not recommended after the 36th week. It should also be avoided during breastfeeding as progesterone can pass into breast milk.
Dosage and Administration
Injesta 1% is administered through intramuscular or subcutaneous injection. The dosage depends on the specific condition being treated and is usually between 5 to 25 mg daily. The treatment duration and dosage should be determined by a healthcare provider.
Side Effects
Common side effects include:
- Heart-related issues such as tachycardia or high blood pressure
- Headaches, dizziness, or mood changes like depression
- Breast tenderness, menstrual irregularities, or reproductive organ changes
- Gastrointestinal symptoms like nausea, bloating, or constipation
- Skin reactions such as rash, acne, or hair thinning
Warnings
Injesta may cause drowsiness or dizziness. It is advised to avoid driving or operating heavy machinery while using this medication. Patients should be closely monitored for signs of blood clot formation, and the medication should be discontinued if these symptoms develop.
Conclusion
Injesta 1% ampoules are an effective solution for managing gynecological issues related to progesterone imbalance. It should be used under medical supervision, and patients should follow the recommended dosage and instructions to avoid complications.
