Description
Metotrexat (Methotrexate) Tablets 10 mg.
Metotrexat (Methotrexate) is a medication commonly used to treat various conditions such as cancer, rheumatoid arthritis, psoriasis, and inflammatory bowel disease. It belongs to a class of drugs known as antimetabolites, which work by interfering with the growth of certain cells in the body. This medication is available in tablet form with a strength of 10 mg. per tablet, and each package contains 50 tablets.
Indications
Metotrexat (Methotrexate) is prescribed for the treatment of the following conditions:
Cancer
Metotrexat is often used in the treatment of various types of cancer, including leukemia, lymphoma, breast cancer, lung cancer, and head and neck cancer. It works by inhibiting the growth of cancer cells and preventing them from spreading to other parts of the body.
Rheumatoid Arthritis
Metotrexat is commonly used to treat rheumatoid arthritis, a chronic autoimmune disorder that causes inflammation in the joints. It helps reduce pain, swelling, and stiffness in the joints, and can also slow down the progression of the disease.
Psoriasis
Metotrexat is an effective treatment option for psoriasis, a skin condition characterized by red, itchy, and scaly patches. It works by slowing down the growth of skin cells and reducing inflammation, leading to improved symptoms and quality of life for patients.
Inflammatory Bowel Disease
Metotrexat can also be used in the treatment of inflammatory bowel disease, including Crohn’s disease and ulcerative colitis. It helps reduce inflammation in the digestive tract and alleviate symptoms such as abdominal pain, diarrhea, and rectal bleeding.
How It Works
Metotrexat (Methotrexate) works by inhibiting an enzyme called dihydrofolate reductase, which is essential for the synthesis of DNA, RNA, and proteins in cells. By interfering with this process, the medication disrupts the growth and division of rapidly multiplying cells, such as cancer cells and cells involved in inflammatory conditions like arthritis and psoriasis.
Dosage and Administration
The dosage of Metotrexat (Methotrexate) can vary depending on the condition being treated, the patient’s age and weight, and other factors. It is important to follow your healthcare provider’s instructions and the dosage recommendations on the prescription label carefully.
Typically, the recommended starting dose for adults with rheumatoid arthritis is 7.5 to 10 mg. once a week, taken as a single dose. For cancer treatment, the dosage may be higher and administered in multiple doses over a specific period of time. Your doctor will determine the most appropriate dosage for your individual situation.
Metotrexat tablets should be taken orally with a full glass of water. It is important not to crush, chew, or break the tablets, as this can alter the medication’s effectiveness and increase the risk of side effects. The tablets can be taken with or without food, but it is recommended to take them at the same time each day to maintain a consistent level of the drug in your body.
If you miss a dose of Metotrexat, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Side Effects
Like all medications, Metotrexat (Methotrexate) can cause side effects in some patients. Common side effects may include:
- Nausea
- Vomiting
- Diarrhea
- Fatigue
- Headache
- Dizziness
- Mouth sores
If you experience any of these side effects and they persist or worsen over time, contact your healthcare provider for further guidance. In some cases, your doctor may adjust your dosage or recommend additional treatment to help manage these side effects.
Serious side effects of Metotrexat may include:
- Signs of infection, such as fever, chills, or sore throat
- Easy bruising or bleeding
- Persistent cough or shortness of breath
- Severe stomach pain
- Yellowing of the skin or eyes (jaundice)
- Unusual tiredness or weakness
If you experience any of these symptoms, seek immediate medical attention as they may indicate a more serious reaction to the medication.
Precautions
Before taking Metotrexat (Methotrexate), inform your healthcare provider about any medical conditions you have, especially:
- Liver disease
- Kidney disease
- Lung disease
- Stomach ulcers
- Any infections
- Blood cell disorders
It is also important to tell your doctor about any other medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and supplements. Some medications may interact with Metotrexat and cause unwanted side effects or reduce its effectiveness.
Metotrexat can have harmful effects on unborn babies, so it is crucial to use effective birth control while taking this medication. If you become pregnant or suspect you may be pregnant while on Metotrexat, notify your doctor immediately.
Do not receive any live vaccines while taking Metotrexat, as the medication may weaken your immune system and make the vaccine less effective. Consult your healthcare provider for guidance on vaccination schedules and recommendations.
Storage
Store Metotrexat (Methotrexate) Tablets at room temperature away from moisture, heat, and direct sunlight. Keep the medication in its original packaging and out of reach of children and pets. Do not use Metotrexat past its expiration date or if the tablets show signs of deterioration, such as discoloration or crumbling.
Conclusion
Metotrexat (Methotrexate) Tablets 10 mg. are a valuable medication used in the treatment of various conditions, including cancer, rheumatoid arthritis, psoriasis, and inflammatory bowel disease. By inhibiting cell growth and division, Metotrexat helps manage symptoms, reduce inflammation, and slow down disease progression.
It is essential to follow your healthcare provider’s instructions regarding dosage, administration, and precautions while taking Metotrexat. Be aware of potential side effects and seek medical attention if you experience any concerning symptoms. By using this medication responsibly and in consultation with your doctor, you can benefit from its therapeutic effects and improve your quality of life.
