Description

Nifurozid (Nifuroxazide) Oral Suspension

Nifurozid, also known as Nifuroxazide, is an oral suspension medication available in a concentration of 200 mg. per 5 ml. It is commonly supplied in a 100 ml. vial for easy administration. This medication is primarily used to treat bacterial infections in the gastrointestinal tract, specifically targeting the intestines. Nifurozid belongs to a class of medications known as nitrofuran derivatives, which work by inhibiting the growth and spread of bacteria responsible for causing infections.

Indications

Nifurozid oral suspension is indicated for the treatment of various gastrointestinal infections caused by susceptible bacteria. These infections may include acute diarrhea, traveler’s diarrhea, gastroenteritis, and other bacterial infections affecting the intestines. It is essential to consult a healthcare professional for a proper diagnosis and treatment plan before using this medication.

Mechanism of Action

Nifurozid exerts its therapeutic effect by interfering with the bacterial cell wall synthesis, ultimately leading to the inhibition of bacterial growth and multiplication. Specifically, it disrupts the enzymatic activity required for bacterial replication, thereby preventing the spread of the infection. Nifurozid targets a broad spectrum of bacteria commonly found in the gastrointestinal tract, making it an effective choice for treating various bacterial infections.

Administration and Dosage

Nifurozid oral suspension should be administered as directed by a healthcare provider or according to the instructions provided on the medication label. The dosage is typically based on the patient’s age, weight, and the severity of the infection. It is important to shake the suspension well before each use to ensure proper mixing of the medication.

For adults and children over 12 years of age, the usual recommended dose is 200 mg. (5 ml) taken three to four times a day. For children between 6 to 12 years old, the dose may be adjusted based on weight, typically ranging from 100-200 mg. (2.5-5 ml) three to four times a day. Children under 6 years old should be dosed based on weight and age, as determined by a healthcare provider.

Adverse Effects

Like all medications, Nifurozid oral suspension may cause certain side effects in some individuals. Common adverse effects may include:

• Nausea
• Vomiting
• Abdominal discomfort
• Headache
• Allergic reactions (rash, itching, swelling)

If any of these side effects persist or worsen, it is important to seek medical attention promptly. In rare cases, more severe adverse effects such as severe allergic reactions or blood disorders may occur. Patients should contact their healthcare provider immediately if they experience any unusual symptoms while taking Nifurozid.

Contraindications

Nifurozid oral suspension is contraindicated in individuals with a known hypersensitivity to nitrofuran derivatives or any of the components of the medication. Patients with a history of allergic reactions to similar medications should avoid using Nifurozid. Additionally, individuals with severe liver or kidney impairment should use this medication with caution and under the supervision of a healthcare professional.

Drug Interactions

It is important to inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking before starting Nifurozid oral suspension. Some medications may interact with Nifurozid and alter its efficacy or increase the risk of adverse effects. Common drug interactions may occur with:

• Warfarin (increased risk of bleeding)
• Metronidazole (increased risk of neurotoxicity)
• Probenecid (reduced excretion of Nifurozid)

Your healthcare provider will be able to adjust your medication regimen or monitor you closely for any potential interactions if necessary.

Storage and Handling

Nifurozid oral suspension should be stored at room temperature away from moisture and heat. It is essential to keep the medication out of reach of children and pets to prevent accidental ingestion. Do not freeze the suspension, and discard any unused medication according to local regulations or guidelines.

Conclusion

In conclusion, Nifurozid oral suspension is a valuable medication used for the treatment of bacterial infections in the gastrointestinal tract. Its mechanism of action, dosage, administration, and potential side effects should be carefully considered before use. Patients should follow the instructions provided by their healthcare provider and report any adverse effects promptly. By understanding the indications, contraindications, and drug interactions associated with Nifurozid, individuals can safely and effectively manage gastrointestinal infections with this medication.