Description

Octreotide 0.05 mg/m 1ml.

Octreotide is a medication that is commonly used to treat various conditions such as acromegaly, carcinoid syndrome, and certain types of tumors. It is available in the form of a solution for injection in vials containing 0.05 mg/m 1ml of octreotide.

Indications

Octreotide is indicated for the treatment of:

• Acromegaly – a condition where the body produces too much growth hormone, leading to abnormal growth of tissues and organs.
• Carcinoid syndrome – a group of symptoms that occur as a result of carcinoid tumors releasing hormones into the bloodstream.
• Gastroenteropancreatic neuroendocrine tumors – tumors that develop in the digestive system and pancreas.

Mechanism of Action

Octreotide is a synthetic analogue of somatostatin, a hormone that inhibits the release of growth hormone, insulin, glucagon, and other hormones. By mimicking the effects of somatostatin, octreotide helps to regulate hormone levels in the body and reduce symptoms associated with hormone overproduction.

Dosage and Administration

The typical dosage of octreotide for adults is 100-600 mcg per day, divided into 2-4 doses. The medication is administered as a subcutaneous injection into the abdomen, thigh, or upper arm. The injection site should be rotated to prevent irritation or lipoatrophy.

Adverse Reactions

Common side effects of octreotide may include:

• Injection site reactions
• Nausea and vomiting
• Abdominal discomfort
• Diarrhea or constipation
• Headache

Serious side effects such as gallstones, pancreatitis, and changes in blood sugar levels may occur in some patients. It is important to report any unusual or severe side effects to your healthcare provider.

Contraindications

Octreotide should not be used in patients who are allergic to octreotide or any of its components. It is also contraindicated in patients with uncontrolled diabetes, gallbladder disease, or a history of pancreatitis.

Drug Interactions

Octreotide may interact with other medications, including:

• Insulin and oral antidiabetic drugs
• Cyclosporine
• Bromocriptine
• Quinidine

Inform your healthcare provider about all medications you are taking to avoid potential drug interactions.

Storage

Octreotide vials should be stored at room temperature (20-25°C) and protected from light. Do not freeze the medication. Once opened, the vial should be used immediately or discarded according to the manufacturer’s instructions.

Conclusion

Octreotide is a valuable medication used in the management of various hormone-related conditions. It works by mimicking the effects of somatostatin to regulate hormone levels in the body. While it may cause some side effects, the benefits of octreotide in controlling symptoms and improving quality of life for patients with conditions such as acromegaly and carcinoid syndrome are significant. It is important to follow the dosage and administration instructions provided by your healthcare provider and report any adverse reactions promptly.