Description

Remestip (terlipressin acetate) 0.1 mg/ml. Ampoules 2 ml. #5

Remestip is a medication containing terlipressin acetate in a concentration of 0.1 mg/ml. It is available in ampoules of 2 ml. each, with a package size of 5 ampoules. Terlipressin acetate is a synthetic analog of vasopressin, a hormone that plays a key role in regulating blood pressure and fluid balance in the body.

Indications

Remestip is commonly prescribed for the treatment of various conditions, including:

• Hepatorenal syndrome
• Variceal bleeding
• Septic shock

Mechanism of Action

Terlipressin acetate works by stimulating V1 receptors in the smooth muscle of blood vessels, leading to vasoconstriction and an increase in blood pressure. It also has anti-diuretic effects, helping to reduce fluid loss and maintain fluid balance in the body.

Dosage and Administration

Remestip should be administered under the supervision of a healthcare professional. The typical dosage and administration guidelines are as follows:

• For hepatorenal syndrome: The usual dose is 1-2 mg. every 4-6 hours, with a maximum dose of 12.5 mg. per day.
• For variceal bleeding: The initial dose is 2 mg, followed by 1-2 mg. every 4-6 hours until bleeding is controlled.
• For septic shock: The recommended dose is 1-2 mg. every 4-6 hours, as needed.

Contraindications

Remestip is contraindicated in individuals with a known hypersensitivity to terlipressin acetate or any of the ingredients in the formulation. It should also be used with caution in patients with a history of cardiovascular disease or hypertension.

Adverse Effects

Common side effects of Remestip may include:

• Nausea
• Headache
• Abdominal cramps
• Hypertension

Severe adverse effects such as myocardial infarction or allergic reactions are rare but may occur in some individuals. It is important to seek medical attention if any unusual or severe side effects are experienced.

Precautions

Before using Remestip, it is important to inform your healthcare provider about any existing medical conditions, allergies, or medications you are currently taking. Pregnant or breastfeeding women should consult with their healthcare provider before using this medication.

Storage

Remestip should be stored at room temperature, away from light and moisture. Keep the medication out of reach of children and pets. Do not use Remestip if the ampoules are damaged or if the solution appears discolored or contains particles.

Conclusion

Remestip (terlipressin acetate) is a medication used to treat conditions such as hepatorenal syndrome, variceal bleeding, and septic shock. It works by increasing blood pressure and reducing fluid loss in the body. While generally well-tolerated, Remestip may cause side effects such as nausea, headache, and hypertension. It is important to follow the dosage and administration guidelines provided by your healthcare provider and seek medical attention if any concerning side effects occur.