Description

Uromitexan (Mesna) 400 mg.

Uromitexan is a medication that contains the active ingredient Mesna, available in the strength of 400 mg. Mesna is a synthetic compound that is used in the prevention of certain side effects associated with chemotherapy drugs, particularly ifosfamide and cyclophosphamide.

Overview

Generic Name: Mesna
Brand Name: Uromitexan

Strength: 400 mg. per ampoule
Concentration: 100 mg/ml.
Volume: 4 ml. per ampoule (400 mg)
Pack Size: 15 ampoules

Indications

Uromitexan (Mesna) is primarily used for the prophylaxis of ifosfamide and cyclophosphamide-induced hemorrhagic cystitis. It helps in reducing the risk of bladder toxicity associated with these chemotherapy agents by binding to their metabolites and rendering them inactive.

Mechanism of Action

Mesna works by detoxifying acrolein, a metabolite of ifosfamide and cyclophosphamide, which is responsible for the urotoxic effects on the bladder. By binding to acrolein and forming a mercapturic acid conjugate, Mesna prevents its harmful effects on the bladder mucosa, thereby reducing the incidence of hemorrhagic cystitis.

Administration

Uromitexan is administered intravenously or orally, depending on the specific treatment regimen prescribed by the healthcare provider. The dosage and duration of treatment may vary based on the chemotherapy drugs being used and the individual patient’s condition.

Adverse Effects

Common side effects of Uromitexan (Mesna) may include:

• Nausea
• Vomiting
• Headache
• Diarrhea

Severe allergic reactions or hypersensitivity to Mesna are rare but may occur. It is important to seek immediate medical attention if any unusual symptoms or reactions are experienced after taking this medication.

Precautions

Before using Uromitexan, inform your healthcare provider about any known allergies, medical conditions, or medications you are currently taking. Mesna may interact with certain drugs, so it is essential to disclose your complete medical history to ensure safe and effective treatment.

Storage

Uromitexan ampoules should be stored in a cool, dry place away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Do not use Uromitexan beyond the expiration date printed on the packaging.

Conclusion

Uromitexan (Mesna) is a valuable medication in the prevention of chemotherapy-induced hemorrhagic cystitis. By neutralizing the toxic metabolites of ifosfamide and cyclophosphamide, Mesna helps in maintaining the integrity of the bladder mucosa and reducing the risk of urotoxicity. It is important to follow the prescribed dosage and administration instructions provided by your healthcare provider to achieve the best therapeutic outcomes while minimizing potential side effects.